Khizaneishvili was born on 26 September 1981 in Tbilisi, the capital city of the Republic of Georgia to a Russian father from Moscow and a Georgian mother.

Fine performances for Georgia in the qualification for the 2006 FIFA World Cup attracted the interest of SC Freiburg, which is known for signing Georgian players.

He scored his first goal for Freiburg in a 3–1 win against Rot-Weiss Essen on 28 January 2007.

[1] In August 2015, Khizaneishvili announced his retirement from professional football.

This biographical article relating to association football in the country of Georgia is a stub.