The club returned to first division football in the Oberliga West in 1948, where a series of strong seasons saw them win divisional championships in 1952 and 1955, as well as finishing runners-up in 1949 and 1954 and third in 1950 and 1953.

The pinnacle of the club's success came with a 2–1 win over Alemannia Aachen in the 1953 DFB-Pokal final, followed by a national championship in 1955 when it beat 1.

The club remained competitive for the remainder of the 1950s, continuing to finish in the division's top half, but 1961 saw a sharp decline leading to relegation from the Oberliga West at the end of the season.

Between 1978 and the end of the century Rot-Weiss was a second- or third-tier club, with just one season spent in the regional Oberliga Nordrhein (IV) in 1998–99.

Bright spots during this period included winning the German amateur championship in 1992 and an appearance in the 1994 DFB-Pokal final, which they lost 1–3 to SV Werder Bremen.

Bundesliga after winning the Regionalliga Nord in 2006, but narrowly missed staying up when they lost the critical final match of the 2006–07 season 3–0 to MSV Duisburg.

Fortuna Düsseldorf, Rot-Weiß Oberhausen and Wuppertaler SV are local rivals when they are playing in the same league (as took place in the 2007–08 season).

In the past, the local derbies versus Schwarz-Weiß Essen were big events, sometimes followed by more than 30,000 fans, however since their rivals decline the rivalry has waned in importance.

[9] The club's honours: Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.