[8] In 2008, Djaba contested the Bole Bamboi seat on the ticket of the NPP but lost to former president, John Dramani Mahama[9] and later became Women's Organizer of the New Patriotic Party.

[12][13] Otiko Djaba was named the 2018 Best African Gender Minister by a Los Angeles film maker, Ms Zuriel Elisie Oduwole, who doubles as an advocate for education.

[15] Prior to the 2016 general election in Ghana, Djaba had called on her Gonja tribes-people to vote John Mahama out because he has not being faithful to them,[16] describing him at a political rally in 2016 as “very wicked, incompetent and desperate".

The second was around her reiterating the assertion that Charlotte Osei offered sexual favors to Mahama in exchange for her position as Electoral Commission of Ghana chairperson.

[19] Despite opposition members walking out of the secret ballot, Djaba obtained 152 favorable votes in excess of the 50% required to secure her the position.