Otis is a city in Rush County, Kansas, United States.

[6] According to the United States Census Bureau, the city has a total area of 0.30 square miles (0.78 km2), all land.

[7] The 2020 United States census counted 296 people, 118 households, and 66 families in Otis.

There were 162 housing units at an average density of 517.6 per square mile (199.8/km2).

35.6% of households consisted of individuals and 19.5% had someone living alone who was 65 years of age or older.

There were 169 housing units at an average density of 563.3 per square mile (217.5/km2).

40.4% of all households were made up of individuals, and 19.8% had someone living alone who was 65 years of age or older.

The racial makeup of the city was 98.77% White, 0.31% Native American, 0.31% Asian, and 0.62% from two or more races.

35.1% of all households were made up of individuals, and 22.3% had someone living alone who was 65 years of age or older.

The Linde Group, based in Munich, Germany, operates the world's second largest helium production facility in Otis, producing nearly one-sixth of the global supply of the gas.

[21] The Otis facility supplies helium to the Macy's Thanksgiving Day Parade, sending nearly 400,000 cubic feet (11,000 m3) in 2008 alone.