Ottavio Cagiano de Azevedo (7 November 1845 – 11 July 1927) was an Italian Cardinal of the Roman Catholic Church.

He later became an abbreviatore del parco maggiore on 1 January 1876, protonotary apostolic ad instar participantium on 9 April 1880 and canon of St. Peter's Basilica on 3 December 1886.

After becoming Apostolic Visitor of the Hospice of Catechumens on 17 January 1911, Cagiano was named Pro-Prefect of the Sacred Congregation for Religious on 12 June 1913, rising to become full Prefect on the following 31 October.

He was made Protector of the Order of the Servants of Mary on 10 March 1914 and then participated in the conclave of 1914, which selected Pope Benedict XV.

During the conclave, Cagiano supposedly served as a scrutineer on the last day of balloting with Cardinals Bartolomeo Bacilieri and Rafael Merry del Val.