Otto Detlev Creutzfeldt (1 April 1927 – 23 January 1992) was a German physiologist and neurologist.

He continued to work for two years as a research anatomist at UCLA Medical School before moving to the Max Planck Institute for Psychiatry in Munich, where he stayed from 1962 to 1971.

In 1971 he became one of the nine directors of the Max Planck Institute for Biophysical Chemistry, as head of the Department of Neurobiology.

Zülch Prize of the Gertrud Reemtsma Foundation awarded posthumously for "Neurophysiology of neuronal correlates of higher behavioral performance, particularly of sight and speech.

From 1992 a lecture is given yearly, and from 1999 biennial, by distinguished scientists to his honour at the University of Göttingen during the Meeting of the German Neuroscience Society ("The Otto-Creutzfeldt-Lecture").