In 1476, it became subject to the Aztec Triple Alliance when Axayácatl conquered Matlatzinca lands.

After the Spanish conquest, the land in the area was redistributed among the Spaniards, with Juana Gamboa getting Tejupilco and Otzoloapan.

The area was probably first evangelized by the Franciscans, and the parish of Otzoloapan was founded by Juan Marqués del Aguila, in 1560 by order of Hernán Cortés.

In the warmer, lower elevations, there are pines, holm oaks, tepehuaje, huizache, truenos, and ash trees, among others.

[1] Agriculture is the most important economic activity in the municipality, mostly growing seasonal crops like corn, with some production of vegetables and fruit.