The Our Lady of Grace Cathedral[1] (Portuguese: Sé Catedral de Nossa Senhora da Graça), also called Cathedral of São Tomé, is a church in the city of São Tomé, capital of the African and island country of São Tomé and Príncipe.

It is the cathedral of the Roman Catholic Diocese of São Tomé and Príncipe.

It stands at Praça do Povo (People's Square) in the city centre, close to the Presidential Palace.

[2] Construction of the first church of Our Lady of Grace was started at the end of the fifteenth century under Captain Álvaro de Caminha.

The last modification was made in 1956, when the church was remodeled in an eclectic revival style, with a neo-romanesque main façade.