Patrice Lumumba Preparatory School (Portuguese: Escola Preparatória Patrice Lumumba, abbreviation: EPLP) is a lyceum located in the southwestern part of the city centre of São Tomé, São Tomé and Príncipe.

It is the oldest secondary school in the country, established in 1952.

[2] The one story building of the former Colégio-Liceu of São Tomé was designed by Lucínio Cruz.

[4] In 1959 it was renamed Liceu Nacional D. João II, after King John II of Portugal.

In 1988, in the midst of reforms of Santomean education, the school was named after Congolese leader Patrice Lumumba.