It is the oldest surviving church building in the city (originally established as the Chapel of St. Anthony of Padua), the back of the church is bordered by Basin Street, and the parish is predominantly African-American.
The church is one of multiple parishes in the city that celebrates a weekly "Gospel Jazz Mass" on Sunday mornings.
The church was built in 1827 and dedicated as a mortuary chapel for victims of yellow fever.
At the time, it was thought that exhalations from the dead could spread the disease, so St Anthony's was established to relieve the burden then stretching St. Louis Cathedral thin.
The statue of Saint Expedite is also visited by Catholics, as well as some local followers of Voodoo.