The church was built in the Romanesque Revival style and designed by Wilfrid Clarence Mangan.

It is located on Acton Lane, on the junction with the Harlesden High Street across from Willesden County Court and All Souls Church.

[3] As there were other missions outside Willesden serving its Catholic population, it was not until 1885 that one was started in the town.

the following year, a temporary chapel, made of iron, was built on Manor Park Road.

On 15 August 1958, the feast of the Assumption, Saint Josemaría Escrivá consecrated Opus Dei to the Virgin Mary there in the church.