The village was named after the nearby ancient city of Uranopolis that was founded by Cassander's brother Alexarchus in the late 4th century BC.

In the 1920s, many Greek refugees from Asia Minor (now Turkey) settled in the village and established rug manufacturing.

[3] In 1926, the old Tower of Prosforion was leased from the monks of Vatopedi to Sydney and Joice Loch who were based there till their deaths in 1955 and 1982.

Ouranoupoli is served by several regular daily buses from the KTEL Chalkidiki bus station in the southern part of Thessaloniki city.

[7] During the summer, there are also cruises for tourists that take visitors on a sightseeing tour of the coast of Mount Athos.