He is the cousin of General Abdul Waheed Kakar, former Chief of Army Staff of Pakistan as well of the martyred Commandant of the Frontier Constabulary, Safwat Ghayur.
He became active in politics in 1996 being one of the founding members of Pakistan Tehreek-e-Insaf led by cricketing hero Imran Khan.
His period as Balochistan governor was controversial, especially following the murder of Nawab Akbar Bugti and Baloch protests against Federal rule.
Ghani admitted there were problems with the law and order situation and drugs in Quetta, the capital of Balochistan, due to instability in neighboring Afghanistan.
Ghani gained a reputation for being tough with militants during his tenure as governor of Balochistan,[4] He is the third man (the first being Rahimuddin Khan and the second being Miangul Aurangzeb) in the history of Pakistan to have held the governorship of two provinces.