Federal Aviation Administration records say this airport had 23,537 passenger boardings (enplanements) in calendar year 2016.

[1] In the year ending April 30, 2018 the airport had 19,991 aircraft operations, an average of 55 per day: 76% general aviation, 13% air taxi, 10% military, and 1% commercial airline.

The next EAS contract was awarded to Big Sky Airlines (Delta Connection), with service to Cincinnati scheduled to begin in June 2007.

On June 30, 2011, Pacific Wings notified the USDOT of their intent to end service at OWB, saying that they were "unable to procure counter or gate space at Nashville International Airport on reasonable terms," and on October 20, 2011 American Airlines code-share partner Cape Air was selected to operate flights to their hub at Lambert–St.

On February 19, 2009 Allegiant Air began flying Owensboro to Orlando Sanford International Airport; it flew to Las Vegas as well.