[8] In January 2016, a group of approximately 40 Owensboro Catholic students drew national attention after Winter Storm Jonas caused their bus to break down on Interstate 76 in western Pennsylvania.

[9] The students were returning from a school-sponsored trip to the March for Life in Washington, D.C., and were stranded in the bus for over twenty hours.

[9][10] In January 2019, a student from Owensboro Catholic High School was observed making comments at the Indigenous Peoples March in Washington, D.C.

The President of Owensboro Catholic Schools, Tom Lilly stated that, "I know that they will use this as an opportunity to make this a teaching moment on the sensitivities involved.

[13] In July 2019, two of the school's faculty members, Cynda Wood and Bretnea Turner, attended the annual Advanced Placement Conference as presenters.