The St. Francis DeSales Roman Catholic Church (Church of St. Francis de Sales) is a historic church building at 116 S. 6th Street in Paducah, Kentucky.

It was built in 1899 and, together with its 1927-built rectory, was added to the National Register of Historic Places in 1979.

[1][2] It is a Classical Revival-style building named for St. Francis de Sales.

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