Using the techniques of histology and radiology, microscopes and other medical imaging are used to locate this pattern of "owl's eye" shaped cells.
The presence of "owl's eye" cells has been linked to a variety of conditions, such as in the pathology of Hodgkin's lymphoma, a form of cancer.
In particular, owl's eye appearance has been used to indicate the presence of cytomegalovirus (CMV), a genus of virus found in humans and other primates.
[8] In a 2000 case study, it was discovered that the owl's eye appearance as a cell body was key for the histopathological understanding of the cytomegalovirus.
[2] The discovery led to a result that owl's eye appearances were a strong sign for finding cytomegalovirus inside organs.
[2] In 2006, a case study journal wrote that owls' eye signs were found in patients with compromised immune system.
[10] A different case study found the appearance of an owl's eye in eighteen patients who were induced with drugs with a syndrome.
[11] The case study concluded that the cytomegalovirus disease was present, as the syndrome caused these patients to compromise their immune system.
The case also found that the significant decrease of white blood cells was a factor in the preliminary stage of cytomegalovirus infection.
In 1985, a journal wrote that the appearance of owl's eye signs was due to the presence of inflammatory bowel disease.
In 2002, a rare case study journal wrote that a range of cytomegalovirus could infect patients diagnosed with AIDS and compromised immune systems.
[17] The skin at the cellular level was found to have owl's eye appearance and was concluded after several tests to be the cytomegalovirus infection.
These scans so far do not indicate that the owl's eye appearance found within radiology has any relevance towards the cytomegalovirus infection within patients.
In 2009, a journal wrote on the presence of an owl's eye appearance that was found within the skeletal structure from the magnetic resonance imaging (MRI) scan in regards to compression of the spinal cord.
In 2012, a case study journal article was written on a 10-year-old boy and discovered the owl's eye appeared inside the brain from an MRI scan.
The owl's eye sign was also detected from the spinal cord in spine MRI scans conducted post-treatment for the boy.
In 2015, a case study on owl's eye sign was found in a neuroimaging via MRI, which was rare due to the patient's diagnosis.