[5] The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stability.

In humans, the PABPs comprise a small nuclear isoform and a conserved gene family of other poly(A)-binding proteins.

[supplied by OMIM][7] PABPC1 is usually diffused within the cytoplasm and concentrated at sites of high mRNA concentration such as stress granules, processing bodies, and locations of high translational activity.

PABPC1 binds to the poly(A) tail and interact with eIF4G, which stabilizes the circularization of mRNAs.

[8] In the nucleus PABP1 binds to the poly(A) tails of pre-mRNAs to facilitate stability, export, transport, and degradation.