512118546ENSG00000183036ENSMUSG00000090223P48539P63054NM_006198NM_008791NP_006189NP_032817Purkinje cell protein 4 is a protein that in humans is encoded by the PCP4 gene.

[5][6][7] Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM).

[8] PCP4 is abundant in Purkinje cells of the cerebellum, and plays an important role in synaptic plasticity.

[8][9] PCP4 knockout mice have been reported to exhibit impaired locomotor learning and markedly altered synaptic plasticity in cerebellar Purkinje neurons.

[8] PCP4 accelerates both the association and dissociation of calcium (Ca2+) with calmodulin (CaM), which is postulated to influence the activity of CaM-dependent enzymes, especially CaM kinase II (CaMK-II).