1MKD, 1OYN, 1PTW, 1Q9M, 1TB7, 1TBB, 1XOM, 1XON, 1XOQ, 1XOR, 1Y2B, 1Y2C, 1Y2D, 1Y2E, 1Y2K, 1ZKN, 2FM0, 2FM5, 2PW3, 2QYN, 3G4G, 3G4I, 3G4K, 3G4L, 3G58, 3IAD, 3IAK, 3K4S, 3SL3, 3SL4, 3SL5, 3SL6, 3SL8, 3V9B, 4OGB, 4W1O, 4WCU5144238871ENSG00000113448ENSMUSG00000021699Q08499Q01063NM_001197221NM_001197222NM_001197223NM_006203NM_001349241NM_001349242NM_001349243NM_001364599NM_001364600NM_001364601NM_001364602NM_001364603NM_001364604NM_011056NM_177252NP_001184150NP_001184151NP_001184152NP_006194NP_001336170NP_001336171NP_001336172NP_001351528NP_001351529NP_001351530NP_001351531NP_001351532NP_001351533NP_001389816NP_001389817cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene.

The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins.

These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003).

[9] This is the subtype of PDE4 that appears to be involved in the emetic and antidepressant effects of PDE4 inhibitors.

[10] Furthermore, changes in expression of the isoform PDE4D7 have been proposed as prostate cancer biomarker.