64857101497ENSG00000090924ENSMUSG00000037552Q9H7P9Q6KAU7NM_022835NM_001351693NM_001351694NM_001083912NM_001290542NM_138752NP_073746NP_001338622NP_001338623NP_001077381NP_001277471NP_620091Pleckstrin homology domain containing, family G member 2 (PLEKHG2) is a protein that in humans is encoded by the PLEKHG2 gene.

[5] In 2002, Himmel et al., used this model of acute myelogenous leukemia and showed that a novel Dbl family guanine nucleotide exchange factor gene is contained downstream of the retroviral uptake site called Evi24.

In addition, DH-PH domains or full-length Clg were introduced into NIH3T3 cells and transformation occurred.

In addition, they showed that GPCR signal-dependent activation of Rac and Cdc42 regulates the chemotaxis of lymphocytes via actin polymerization.

In 2016, Edvardson et al., identified homozygosity for Arg204Trp mutation in the PLEKHG2 gene in the patients with dystonia or postnatal microcephaly.