57449269608ENSG00000171680ENSMUSG00000039713O94827Q66T02NM_001265593NM_001265594NM_020631NM_001004156NM_001285999NM_001374783NP_001252523NP_065682NP_941374NP_001272928NP_001361712Pleckstrin homology domain containing, family G member 5 (PLEKHG5) is a protein that in humans is encoded by the PLEKHG5 gene.

This gene encodes a protein which catalyzes the exchange of GDP for GTP within the small GTPase RhoA which in turn modulates the activation of mDia or Rock kinase to influence cell polarization.

It is known to interact with the Crumbs polarity complex by binding to either of the multi PDZ domain adapter proteins Patj or Muc-1.

This protein has also shown to be highly expressed in several glioma cell lines, and is likely a driver of tissue invasion.

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