PLOS Genetics is a peer-reviewed open access scientific journal established in 2005 and published by the Public Library of Science.

[1] The founding editor-in-chief was Wayne N. Frankel (Columbia University Medical Center).

The current editors-in-chief are Aimée Dudley (Pacific Northwest Research Institute) and Anne Goriely (MRC Weatherall Institute of Molecular Medicine).

The journal covers research on all aspects of genetics and genomics.

[10] Since its tenth year of publication, the journal annually awards the $5000 PLOS Genetics Research Prize for the best paper published in the previous year based on nominations from members of the genetics community.