Midland Loan Services, a division of PNC Real Estate based in Overland Park, Kansas and founded in 1991, is ranked by Mortgage Bankers Association as the second largest master and primary servicer of commercial bank and savings institution loans.

[8] In 1858, the company located its corporate offices to the corner of Fifth Avenue and Wood Street in Pittsburgh, where they remain to this day.

[24][27][28] On October 26, 2007, PNC acquired Yardville National Bancorp, a small commercial bank centered in central New Jersey and eastern Pennsylvania.

[30] On April 4, 2008, PNC acquired Sterling Financial Corporation, a commercial and consumer bank with accounts and branches in central Pennsylvania, northeastern Maryland and Delaware.

[38] In July 2010, PNC sold its Global Investment Servicing (GIS) subsidiary to The Bank of New York Mellon to repay funds from the Troubled Asset Relief Program, which had been used for the National City acquisition (see above) in 2008.

[51] On October 2, 2015, the bank opened Tower at PNC Plaza, its new headquarters on the corner of Fifth Avenue and Wood Street in downtown Pittsburgh.

[53] The LEED Platinum building, owned by PNC and designed by Gensler, won awards for its environmentally friendly features.

[55][56] In November 2017, the company acquired The Trout Group, an investor relations and strategic advisory firm servicing the healthcare industry.

[59][60] The company ranked one hundred sixty fifth on the 2018 Fortune 500 list of the largest United States corporations by revenue.

[61] In 2018, PNC began opening "Solution Centers", a hybrid between traditional bank branches and ATM–only services, mostly serving new markets.

Through this method, PNC expanded its retail footprint into Boston, Denver, Kansas City, Nashville, and several markets in Texas including Austin, Dallas, Houston, and San Antonio.

In August 2019, PNC launched a Fintech incubator subsidiary called "numo" that functions as an internal startup.

In December 2013, the Department of Justice and the Consumer Financial Protection Bureau announced that they had reached an agreement with National City Bank to resolve allegations that the bank had charged Black and Hispanic borrowers higher prices for mortgages between 2002 and 2008, before the acquisition by PNC.

Bariteau claimed PNC let the chairman of the Military Channel make unauthorized withdrawals of millions of dollars from the company's account for personal use.

[69] In June 2003, PNC Bank agreed to pay $115 million to settle federal securities fraud charges after one of its subsidiaries fraudulently transferred $762 million in bad loans and other venture capital investments to an AIG entity in order to conceal them from investors.

[70] In 2017, PNC agreed to pay $16 million to settle claims of overtime wages by loan officers under the Fair Labor Standards Act.

[71] According to a lawsuit, funds entrusted to National Prearranged Services (NPS), a St. Louis–based company that sold prepaid funerals, were diverted and embezzled.

[74] In 2015, PNC was one of 22 companies that violated disclosure requirements for municipal bonds by failing to divulge that the issuers had filed late financial reports.

[75] Beginning in 2010, until it changed its policy in February 2015, PNC was the subject of protests by the Earth Quaker Action Team, led by George Lakey, and the Rainforest Action Network due to its funding of companies engaged in mountaintop removal mining in Appalachia.

The protests included political demonstrations at branches and offices and the annual general meeting, fasting, and boycotts.