For example, the phosphorylation of serine 112 will inhibit PPARG function, and enhance adipogenic potential of fibroblasts.

The genes activated by PPARG stimulate lipid uptake and adipogenesis by fat cells.

[20] The activation of PPAR gamma by these and other ligands may be responsible for inhibiting the growth of cultured human breast, gastric, lung, prostate and other cancer cell lines.

[23] PPARG is required for epithelial differentiation of trophoblast tissue, which is critical for proper placenta vascularization.

[11] Peroxisome proliferator-activated receptor gamma has been shown to interact with: PPAR-gamma agonists have been used in the treatment of hyperlipidaemia and hyperglycemia.

[37] This article incorporates text from the United States National Library of Medicine, which is in the public domain.