Heading east from Adjuntas, PR-143 runs through the northern border of the municipality of Ponce, before reaching Orocovis and then Barranquitas.

It crosses Toro Negro State Forest, and leads to such landmarks as Cerro de Punta and Lago El Guineo lake.

[5] The Orocovis-Villalba lookout and Cerro Maravilla as well as a number of local restaurants can be found along the way.

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