3TNP, 3TNQ, 4WBB, 4X6Q557719088ENSG00000005249ENSG00000284096ENSMUSG00000002997P31323P31324NM_002736NM_011158NM_001364407NM_001364408NP_002727NP_002727.2NP_035288NP_001351336NP_001351337cAMP-dependent protein kinase type II-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR2B gene.

[5][6] cAMP is a signaling molecule important for a variety of cellular functions.

The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits.

Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity.

The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.