The album features guest appearances from rappers 2 Chainz, Big K.R.I.T., Dave East, Rapsody, Roc Marciano, Yelawolf, Chavis Chandler, bassist Brady Watt and singers Novel (as a part of duo Summer of '96 with Wonder), CeeLo Green and Denaun Porter.

"[1] Scott Glaysher of XXL compared it to their previous album and noted the varying content that Royce frequently switched from: "Despite PRhyme 2 being twice as long as its nine-track predecessor, Premier never defaults to redundant sounds.

"1 of the Hardest" loops a head-banging guitar riff, "Era" uses twinkly synths that rapidly alternate between left and right speaker channels, "Flirt" sports a classic New York bassline and chorus that nods to Camp Lo's "Luchini"—and that's just to name a few of the album's different flavors.

[11] Karas Lamb at Consequence of Sound appreciated the "building bridges between hip-hop's veterans and rising icons, who will predict the size and shape of the next wave", but felt that Royce's "appetite for glory also makes room for ego and showmanship to muddy the final mix".

[10] Jonah Bromwich of Pitchfork was also interested in the choice, stating that it was an "unusual constraint" and said that "sometimes, the veteran Detroit rapper [Royce] transcends his natural Buddenism, avoiding corny punchlines, esoteric lyrical easter eggs, and bars that lead him nowhere.