The second Alice Dean made her maiden trip from Cincinnati on February 25, 1864, with the same captain, James H. Pepper.
On March 25, 1864, she hit bank ten miles below Cincinnati on a down-bound trip and sank with her stern in 12 feet of water.
The Jennie Hubbs and Lady Pike took off her freight, and her passengers boarded the ship Kate Cassel.
In December 1869 about 40 miles above Memphis she hit a log and would have sunk save for a cargo of cotton which buoyed her up until the Thompson Dean came along to assist.
The machinery went to the Thompson Sherlock and the hull was used as a wharfboat at Lake Providence, Louisiana, with the upper work still intact until a gale blew off the cabin in August 1865.