Commercially, it reached number one in Taiwan, and was a top 20 hit on record charts in Mexico, Chile, Puerto Rico, Ecuador, El Salvador, Peru and Venezuela, among other Latin American countries.

"Pa Mis Muchachas" is Aguilera's first single in Spanish since her rendition of "Hoy Tengo Ganas de Ti" with Alejandro Fernández in 2013.

[7] Like the rest of La Fuerza,[8] the song's lyrical content focuses on female empowerment, serving as "an homage to women", with Aguilera noting that.

[11]: 06:20  Because of its theme, "Pa Mis Muchachas" has been compared to previous songs with feministic undertones recorded by Aguilera — including "What a Girl Wants" and "Can't Hold Us Down".

[12] After teasing the single through several teaser videos on her social media,[13] Aguilera eventually announced "Pa Mis Muchachas" and Becky G, Nicole and Peluso as her collaborators on October 19, 2021.

[19][20] Aguilera performed the song again during her live-streamed show at the Hollywood Palladium organized in celebration of the 35 year partnership between Citi and American Airlines on October 6, 2022.

Harper's Bazaar writer Bianca Betancourt noted that "Aguilera's signature vocals shine over the infectious guaracha-style beat — a high-tempo genre that stems from Cuba" adding that "it's the best she's sounded in years".

[24] They went on to say that her "show-stopping delivery" complimented the accompanying voices of Becky G, Nicki Nicole, and Nathy Peluso and that the song "unites some of the boldest powerhouses in Latin music and culture, heating up each verse".

[24] Paige Mastrandrea of Ocean Drive praised the song for its "nostalgic vibe" that the audiences were "craving from" Aguilera since her previous female collaboration — 2001's "Lady Marmalade",[5] a sentiment also shared by Enrique Cerros of NEIU Independent.

[25] Billboard considered the song "a modern-day girl-power anthem that honors the Latinas that came before us",[26] and Rolling Stone's Lucas Villa simply labelled it as "mighty".

[27] Writing for Atwood Magazine, Josh Weiner found the song "extraordinary", a "delight", and "one of the most energetic numbers Aguilera’s produced in recent memory".

opined that "Pa Mis Muchachas" "overflows with spirit, strength, soul and style", and noted that the performers "make each verse of the song explode with emotion".

[34][35] "Pa Mis Muchachas" debuted and peaked at number 3 on the Billboard Latin Digital Song Sales on the chart issue dated November 6, 2021.

[40] It was a top-ten airplay hit in Chile,[41] Dominican Republic,[42] El Salvador,[43] Guatemala,[44] Panama,[45] Peru,[46] Puerto Rico,[47] and Suriname.

[64][11]: 5:40 The scene in which Aguilera drinks tequila straight from the bottle and sensually dances with another woman was inspired by the 2002 biographical film Frida, specifically a similar, homoerotic sequence featuring Salma Hayek and Ashley Judd.