Early in his career, Burchuladze sang Leporello (Don Giovanni), Prince Gremin (Eugene Onegin), and King Rene (Iolanta) for the Tbilisi Opera House.

He debuted at the Covent Garden in 1984 as Ramfis (Aida) and then appeared as Don Basilio (The Barber of Seville), Khan Konchak (Prince Igor), Boris Godunov, and the Inquisitor (Fiery Angel).

[1][2][3] According to the musicologist Elizabeth Forbes, Burchuladze's "magnificent dark-toned voice and imposing stature are ideal for both the Russian repertory and Giuseppe Verdi's bass roles".

[6] In November 2015, Burchuladze established the Georgian Development Foundation, a civic movement, which was expected to turn into a political party ahead of the scheduled October 2016 parliamentary election.

He set up offices in Washington and Los Angeles with the declared aim to raise awareness of Georgia in the United States, whose help, according to Burchuladze, was essential in reducing threats coming from Russia.