He was the head coach of Real Madrid for eleven seasons from 2011 to 2022, guiding them to two EuroLeague championships and six ACB titles.

Laso played 17,378 minutes (4th most) in 624 games (9th most) in the Liga ACB (the top-tier level Spanish League).

During the 2014 ACB Playoffs Real Madrid played a rematch of the 2014 Euroleague Final Four semifinal against FC Barcelona Bàsquet.

The coach would be ejected from the game by referees early in the second half and was wheeled from the arena escorted by security.

Real had consulted doctors and cardiologists who said it would be a risk for Laso's health if he continued his job as head coach.