Born in Rosario, Pérez graduated from Newell's Old Boys' youth setup, and made his professional debut on 2 December 2006, in a 2–2 draw with Godoy Cruz.

[3] On 31 July 2009 Pérez moved abroad for the first time in his career, joining Ecuadorian Serie A side Emelec on loan until the end of the season.

Pérez scored eight goals in his return campaign, and appeared regularly in the following two seasons, also being a part of the squad which won the 2013 Torneo Final.

[17] On 15 February 2024, Pérez returned to Newell's Old Boy to play a friendly match against Inter Miami CF, a clause included in his contract when he joined the club.

[22] He made full international debut on 27 March, coming on as a second-half substitute for Éver Banega in a 6–1 loss against the latter at the Wanda Metropolitano in Madrid.