Paganico is a village in the province of Grosseto, in southern Tuscany, central Italy.

It lies in the valley of the Ombrone river, at 66 meters above the sea level.

The town is of medieval origins, as it was founded in the 13th century by the Republic of Siena in a strategical location overlooking the valley towards the Sienese core lands.

Sights include the Church of St Michael Archangel, built in the 13th-14th centuries.

It houses a series of 14th-century frescoes (1368), attributed to the Sienese painter Biagio di Goro Ghezzi and his workshop and depicting the Stories of St. Michael, a 15th-century crucifix, and other Renaissance paintings.