Throughout the Middle Ages Pagazzano maintained its characteristics of a small agricultural village with limited strategic-military appeal, despite its central position along the axis of Crema-Bergamo.

In the eleventh century Pagazzano already gravitated in the Milanese political and military orbit to find itself in 1300 in the possession of the Viscounts who built a castle here between 1450 and 1475.

Pagazzano and specifically its castle were the object of interest in the age-old opposition between the Visconti-Sforza and the Serenissima (Republic of Venice), passing repeatedly from one state to another, without however improving the socio-economic conditions of the inhabitants of the village.

The Spanish period was the hardest for the community of Pagazzano, which - beyond the misgovernment of the new rulers - had to suffer abuses and robberies that blocked the economic and demographic development, possibly contributing to its regression.

The improvement of the socio-economic conditions of the community during the Austrian period allowed the demographic development that had come to a halt as well as an increase in agricultural production.