In 2001, Davis became the host of the TLC cable network's redecorating television series Trading Spaces, replacing Alex McLeod.

There was some media speculation that TLC's decision was in part motivated by Davis's appearance in TV Guide "wearing nothing but wallpaper"[5] and her performance of a faux striptease in a "Broadway Bares/Equity Fights AIDS" charity event.

"[12] She also was a contestant on the summer 2006 CBS television series Gameshow Marathon, in which celebrities participated in recreations of classic game shows with their winnings going to charity.

She praised the new TLC executive team and its intention to keep Trading Spaces fresh, while at the same time maintaining the original mission of the show.

[15] In mid-2007 she took over the title role in the national touring production of the Broadway revival Sweet Charity, replacing Molly Ringwald through the end of the show's scheduled run on August 12, 2007.

Don Aucoin of The Boston Globe praised the performance as providing "the emotional depth and nuance of personality that can only be achieved by an actress who understands her character inside and out.

Artistic Director Karen Azenberg will direct and choreograph the production at the Salt Lake City professional regional theatre.

In September 2008, Eastman Kodak Company formed a U.S. partnership with Trading Spaces and with Davis to encourage people to explore their creativity with their photos.

Davis became Kodak's celebrity spokesperson with the media through March 2009, sharing Kodak-inspired projects and ideas in the weekly design show, 30-second TV spots, on-line tips, videos, and a custom-published magazine.