Although, the album received a mixed reception from critics, Pain Is Love debuted at number one on the Billboard 200 and was supported by four singles: "Livin' It Up", "I'm Real (Murder Remix)", "Always on Time" and "Down Ass Bitch".

[4] AllMusic's Jason Birchmeier praised the album for fine-tuning the formula set by Rule 3:36 of having R&B crossover singles and hardcore rap tracks to balance out the whole record.

[1] An editor from HipHopDX said that hardcore tracks like "Dial M for Murder" and "Worldwide Gangsta" felt like forced attempts to bring back Ja's thug persona, but praised the album for having tracks that contain ear-grabbing lines and good beats, saying that "Pain Is Love is another positive establishment that will indeed create more popularity and more fan acknowledgement for Ja Rule.

"[8] Soren Baker of the Los Angeles Times gave credit to the singles "Livin' It Up" and "I'm Real" for being the album's strong points but criticized tracks like "The Inc" and "Worldwide Gangsta" for being bland and less effective, saying they "recycle hard-core themes without adding any clever phrasings or creative beat work to compensate for their ordinariness.

Club criticized the album for lacking substance to go with the catchy pop hooks and Ja for making what they perceive as failed attempts to copy 2Pac, specifically on the penultimate feature track "So Much Pain" concluding that "even at less than his best, 2Pac still conveys a sense of urgency and purpose that illustrates incontestably the huge chasm separating the real deal from a canny imitation.