Paing Phyo Thu is considered one of the promising and prominent actresses in Myanmar.

Her performances as child actor stood out and she became an actress in Myanmar major films in later years.

In 2017, she was cast to play a lead role in the film Mi which is based on the novel by one of the most prominent Myanmar novelists, Kyi Aye.

[5][6] Following the 2021 Myanmar coup d'état, Paing Phyo Thu was active in anti-coup movements both in person at rallies and through social media.

[8][9] On 2 April 2021, warrant for her arrest was issued under section 505 (a) of the Myanmar Penal Code by the State Administration Council for speaking out against the military coup, calling for participation in the Civil Disobedience Movement (CDM) and supporting the Committee Representing Pyidaungsu Hluttaw.