Doggy Don is an anthropomorphic little pink dog, who resides in the modern suburbs of an unspecified location somewhere in South India.

Ranging from stealing food to framing others for their own misdeeds and even hijacking vehicles to go on joyrides, the mice will go to any length possible to wreak havoc and irritate the people around them and escalate their situations to extremely outrageous heights, usually, but not exclusively the dogs.

Doggy Don and Karnal take a trip to the future and befriend a cat named Billiman, who turns out to be a villain in a facade and conquers the city.

Doggy Don, Karnal and their brother, Major Saab along with the mice are urged to save the world from an evil shark, called Surmai Bhopali, who destines to transform the world into an ocean only resided by sea creatures by the destroying the balance between sea and land, which is located at the heart of the ocean.

Along with their new friends, Boodhababa, Manumaan and Yeti, they defeat Surmai and successfully capture him and his fish army in a jail.

Doggy Don, Karnal and the mice brothers try to save the world from an alien monkey named Hyper Bunder.