[26] In 1956, President Dwight Eisenhower requested permission from Pakistan's new Prime Minister, Huseyn Suhravardie, to lease the Peshawar Air Station (PAS), which was to be used in intelligence gathering of Soviet intercontinental ballistic missiles.

In 1960, Ayub Khan granted permission for the United States to fly its first spy missions to the Soviet Union from the Peshawar Air Base, which had been recently upgraded with American funds.

[30] Additionally, Ayub Khan was disappointed that Pakistan's decision not to take advantage of Indian vulnerabilities during its war with China was not rewarded with serious United States efforts in negotiations to settle the Kashmir dispute.

Bhutto authorized the construction of Chagai weapon-testing laboratories, whilst the United States opposed the action and predicted that it will lead to a massive and destructive war between India and Pakistan in the future.

Reagan sold Pakistan $3.2 billion worth of attack helicopters, self-propelled howitzers, armoured personnel carriers, 40 F-16 Fighting Falcon warplanes, nuclear technology, naval warships, and intelligence equipment and training.

[51] It was widely reported in Pakistan that the U.S. Assistant Secretary of State Teresita Schaffer had told the Foreign Minister Shahabzada Yaqub Khan to halt the uranium enrichment programme.

[51] After France's project was cancelled, Nawaz Sharif successfully held talks with the China to build the largest commercial nuclear plant, CHASNUPP-I in Chasma city in Pakistan.

"Today's signing represents a promise kept and another milestone in our expanding partnership," US Ambassador Nancy Powell said in a statement, "The forgiveness of $1 billion in bilateral debt is just one piece of a multifaceted, multi-billion dollar assistance package."

[57] Prior to the September 11 attacks in 2001, Pakistan and Saudi Arabia were key supporters of the Taliban in Afghanistan, as part of their "strategic depth" objective vis-a-vis India, Iran, and Russia.

Having failed to convince the Taliban to hand over bin Laden and other members of Al Qaeda, Pakistan provided the U.S. a number of military airports and bases for its attack on Afghanistan, along with other logistical support.

[citation needed] Since 2001, Pakistan has arrested over five hundred Al-Qaeda members and handed them over to the United States; senior U.S. officers have been lavish in their praise of Pakistani efforts in public while expressing their concern that not enough was being done in private.

In February 2010, US President Barack Obama sought to increase funds to Pakistan to "promote economic and political stability in strategically important regions where the United States has special security interests".

The attack on the US embassy and the NATO headquarters in Kabul were blamed on the Haqqani Network, which US Admiral Mike Mullen called "a veritable arm of Pakistan's Inter-Services Intelligence Agency.

It was reported in 2011 that academics and journalists in the United States have been approached by Inter-Services Intelligence spies, who threatened them not to speak about the Balochistan independence movement, as well as human rights abuses by the Pakistani Army, or else their families would be harmed.

The compound itself, although unusually tall, was less conspicuous than sometimes envisaged by Americans, given the common local habit of walling off homes for protection against violence or to ensure the privacy of female family members.

"[125] In 2012, Shakil Afridi, a doctor who had set up a fake vaccination campaign – in cooperation with the United States in searching for Al Qaeda and bin Laden – was convicted of treason by Pakistan, and sentenced to 33 years in prison.

[129][130] Following years of poor inter-governmental relations, the two countries began to cooperate more closely – particularly following the United States' use of drone missiles to strike at Pakistan's most-wanted militant Mullah Fazlullah on November 24, 2014, whom they "narrowly missed".

[132] Following an unprecedented two-week-long visit by Pakistan's most senior military official Gen. Raheel Sharif, Rep. Adam Schiff stated that US-Pakistani relations were on the upswing following several tense years of dysfunction.

[134] On 7 May 2015, according to an internal report prepared by Congressional Research Service, Pakistan has made full payment from its national funds towards the purchase of 18 new F-16C/D Fighting Falcon Block 52 combat aircraft worth US$1.43 billion.

[150] During the 2022 Pakistani constitutional crisis, Imran Khan blamed the US officials Donald Lu and named the United States as the country in question over a "threatening letter", warns American "regime change" led to his downfall.

"[152] In a statement released at the end of the 'Fourth Annual US-India 2+2 Ministerial Dialogue', the United States and India call on Pakistan to take "irreversible action" to ensure that its soil is not used for terrorist attacks against any other country.

[156] In April 2023, a secret memo written by Pakistani Minister of State for Foreign Affairs Hina Rabbani Khar was leaked to the press where she called for prioritizing ties with China over appeasing the U.S. within the context of the U.S.-China geopolitical rivalry.

[157] In response to the crackdown on former Prime Minister Imran Khan, Pakistani-American advocacy groups were mobilizing members of the US Congress to issue statements against human rights abuses in Pakistan, further estranging the bilateral relationship.

[158] In August 2023, according to a leaked diplomatic cable at the March 7, 2022 meeting from Pakistan received by The Intercept, US State department encouraged removal of Imran Khan owing to his neutral stance on the Russian invasion of Ukraine.

[161] Earlier in the same month, Democratic lawmakers urged President Biden and Secretary of State Antony Blinken to delay recognition of the new Pakistani government until thorough investigations into election irregularities were completed.

On 19 December 2024, a senior White House official said Pakistan is developing long-range ballistic missile capabilities that eventually could allow it to strike targets well beyond South Asia, making it an "emerging threat" to the United States.

[175] On 31 May 2012, Senator Rand Paul (R-Kentucky) called for the United States to suspend all aid to Pakistan and grant citizenship to a doctor who was jailed for helping hunt down Osama bin Laden.

[177] On 5 January 2018, US suspended about $2 billion in security aid to Pakistan for failing to clamp down on the Afghan Taliban and the Haqqani Network terror groups and dismantle their safe havens, a White House official said.

[178] The freezing of all security assistance to Pakistan comes after President Donald Trump in a New Year's Day tweet accused the country of giving nothing to the US but "lies and deceit" and providing "safe haven" to terrorists in return for $33 billion aid since 2003.

[180] According to The Economic Times, Pakistani Foreign Minister Shah Mehmood Qureshi stated, "The USD 300 million is neither aid nor assistance – it is the money Pakistan spent from its resources against militants and in the war against terrorism.