The mission of PNRA is to protect the public, radiation workers and environment from the harmful effects of ionizing radiation by formulating and implementing effective regulations, building a relationship of trust with licensees, and maintaining transparency in its actions and decisions.

The agency was established in 2001 after the President of Pakistan Justice (retired) Rafiq Tarar signed the executive decree, 'Pakistan Nuclear Regulatory Authority Ordinance No.III' in 2000.

Established by Pakistani scientists, the regulatory regime was significantly improved when, in 1971, the Karachi Nuclear Power Plant was commissioned.

ICD also liaises with other governmental departments regarding visits of experts coming to PNRA from the IAEA and, through bilateral agreements, from other regulatory bodies.

It coordinates with Pakistani Embassies abroad for visas, concerned government departments for security matters, PAEC and IAEA.