The Palacio de Santoña (English: Palace of Santoña) is a palace located in Madrid, Spain, originally constructed for the Duke of Santoña.

It was declared Bien de Interés Cultural in 1995.

[citation needed] It is a sixteenth century building, renovated in the eighteenth century by the architect Pedro de Ribera, and in the nineteenth century by Antonio Ruiz de Salces [es].

The Candidates Tournament 2022 in chess was held at the Palacio from June–July 2022.

This article about a palace in Spain is a stub.