The Palacio del Obispado, Spanish for Bishop's Palace, also known as El Obispado or the Bishop's Museum, originally called Palacio de Nuestra Señora de Guadalupe, is an 18th-century colonial building, located in Monterrey, Nuevo León state, Northeastern Mexico.

[2] During the reign of Charles III of Spain and through a bull issued by Pope Pious VI in 1777, the Diocese of Linares was erected for the town of the same name.

At the request of the king, the Pope named the palace the diocese of Antonio de Jesús Sacedón, who received his assignment in 1779 through a representative who took possession of the building with all its rites.

The size of its main facade in its Baroque style and its stipe (inverted copyramidal column or pillar) highlights the grandeur of its dome, completed in 1853 and 1857.

The building is built of ashlar stone, a characteristic material of the region, and is one of the few examples of viceregal architecture that are still preserved in northeastern Mexico.