Palagnedra is a village and a locality part of the municipality of Centovalli[1] in the district of Locarno in the canton of Ticino in Switzerland.

Lago di Palagnedra is located below the village, on the Melezza river.

[2] During the Middle Ages, Palagnedra was the administrative and religious center in the 13th-century Centovalli valley community.

It was the mother church of the Centovalli valley and contains the best preserved late gothic cycle of frescoes by Antonio da Tradate.

[3] A large part of the community of Palagnedra is formed by the notorious family name "Mazzi" The former municipality is located in the Locarno district on a terrace on the southern slope of the Centovalli.