Palairos (Greek: Πάλαιρος) is an ancient city and a modern town in Aetolia-Acarnania, Greece.

The construction of the walls interchanges between the square-shaped and the polygonal system and the parts belong to different periods.

It lies high in the mountains overlooking the Ionian Sea and Lake Vourkaria.

During antiquity it was part of Acarnania, according to the Theodorokoi, situated on the west coast, on the Ionian Sea, which is placed by Strabo between Leucas and Alyzia.

[7] In the first year of the Peloponnesian War (431 BCE) Palairos was in alliance with the Athenians; and when the latter people took the neighbouring town of Sollium, which was a Corinthian colony, they gave both it and its territory to the inhabitants of Palaerus.