The palace was built around 1575 by Alessandro Moschetti for count Girolamo Gabrielli, of a noble family from Gubbio.

The chosen location was at the edge of the Pincian hill, over what remained of the fabled gardens of Lucullus.

In the 16th century the area was still considered periurban, and the palace was the first monumental building erected there.

After having been rented to different institutions from the late 18th century onwards, the building became the property of the Holy See in 1887, and on that occasion was restored and enlarged by Andrea Busiri Vici.

Palazzo Gabrielli-Mignanelli is today the residence of Valentino Garavani as well as the Roman headquarters of his maison.