[4] The site of Palazzo Parisio originally contained two town houses, which belonged to Fra Michel Fonterme dit la Chiesa and Francesco This.

[7] After the French invasion of Malta, Napoleon stayed at Palazzo Parisio for six days from 12 to 18 June 1798, before embarking on the Egyptian campaign.

On 26 November of that year, Ralph Abercrombie arrived in Malta on board HMS Diadem, and stayed at the palace until he left for Egypt on 20 December.

From 25 January to 14 May 1841, Lord Lynedoch, a personal friend of Parisio Muscati, also took up temporary residence at the palace during his stay in Malta.

[8] The de Piro family had eventually came to an agreement with the British government to exchange the palace with Casa Caccia.

In 1886 the postmaster-general, Ferdinand Inglott, persuaded the owners to lease, and eventually to sell, the palace to the government.

The central mail room, registered letter branch and poste restante were moved to the former Garrison Chapel, which is now occupied by the Malta Stock Exchange.

[6] Palazzo Parisio was designed by the architect Peruzzi,[19] and it contains elements from both neoclassical[20] and baroque architecture.

[6] The ceilings and walls of the palace have a number of frescoes painted by the Maltese artist Antonaci Grech.