The Palazzo Pepoli Vecchio is a Medieval palace located on Via Castiglione number 8, in central Bologna, region of Emilia-Romagna, Italy.

The merlonated brick Gothic-style building is now the civic Museum of the History of Bologna.

It stands across the street from the Baroque-style Palazzo Pepoli Campogrande, now a civic art gallery.

In 1344, Taddeo Pepoli, son of Romeo, commissioned the building of the palace.

After the death of Agostino Siero Pepoli, the palace was ceded to the municipality.