In 1940 the palace was dismantled and rebuilt with a different footprint along the north side of the new avenue, constructed between 1936 and 1950, which links St Peter's Basilica and the Vatican City to the center of Rome.

The palace is located in the Borgo rione of Rome along the north side of Via della Conciliazione avenue, its main facade facing south.

The north side of the building borders two other reconstructed Renaissance edifices of Borgo: the Palazzo Jacopo da Brescia and the house of the physician of Paul III.

[3] This building, once owned by Roberto Strozzi (exponent of the banker family from Florence), had been sold in 1567 to Pope Pius V, who donated it immediately to his nephew Paolo Ghislieri.

[3][5] After Fontana's transferral to Naples who, after the death of Sixtus V (r. 1585–90) and the brief intermezzo of Innocent IX (r. Oct.-Dec. 1591), could not win the favor of Pope Clement VIII (r. 1592–1605), the task was finished by his nephew Carlo Maderno.

[7] Around 1630 the palace housed for a brief time the Collegio Nazareno, one of the oldest schools in Rome, founded in those years by Joseph Calasanz, and presently in Via del Bufalo, in Trevi rione.

[6] After that, the Rusticucci's heirs sold the building to Mario Accoramboni, member of a family of lesser nobility which had emigrated from the umbrian town of Gubbio to Rome.

[6] In 1940, because of the construction of the Via della Conciliazione, it was demolished[9] and partially rebuilt in the same year with design by Clemente Busiri Vici, exponent of a Roman dynasty of architects.

[7] When the shop was reopened several years after the capture of Rome on 20 September 1870, hosting first a pizzeria, then the aforementioned bakery, the rooms were renovated, and all the sketches were lost.

[14] Resulting from the union of several small houses, the edifice was very long, especially after the addition of another wing at the west end, along Via del Mascherino, sixty years after the death of Rusticucci in 1603.