[6] When oxygenic photosynthesis evolved in cyanobacteria during the Mesoarchean, the increasing amount of byproduct dioxygen began to deplete the reductants in the ocean, land surface and the atmosphere.

[7] At the beginning of the preceding Archean eon, almost all existing lifeforms were single-cell prokaryotic anaerobic organisms whose metabolism was based on a form of cellular respiration that did not require oxygen, and autotrophs were either chemosynthetic or relied upon anoxygenic photosynthesis.

This was compounded by a 300-million-year-long global icehouse event known as the Huronian glaciation — at least partly due to the depletion of atmospheric methane, a powerful greenhouse gas — resulted in what is widely considered one of the first and most significant mass extinctions on Earth.

The Palaeoproterozoic represents the era from which the oldest cyanobacterial fossils, those of Eoentophysalis belcherensis from the Kasegalik Formation in the Belcher Islands of Nunavut, are known.

[17][18][19] Statherian fossils from the Changcheng Group in North China provide evidence that eukaryotic life was already diverse by the late Palaeoproterozoic.